Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

Srinivasan Ayyanaar, Mookkandi Palsamy Kesavan, Chandrasekar Balachandran, Swetha Rasala, Perumal Rameshkumar, Shin Aoki, Jegathalaprathaban Rajesh, Thomas J. Webster, Gurusamy Rajagopal

Research output: Contribution to journalArticle

Abstract

This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.

Original languageEnglish
Article number102134
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume24
DOIs
Publication statusPublished - Feb 2020

Fingerprint

Lecithin
Curcumin
Microspheres
Iron oxides
Nanoparticles
Lecithins
Cytotoxicity
Pharmaceutical Preparations
Reactive Oxygen Species
Oxygen
Medical applications
Antioxidants
HeLa Cells
Cells
Inhibitory Concentration 50
Anti-Inflammatory Agents
ferric oxide
Targeted drug delivery
Cell Line
polylactic acid-polyglycolic acid copolymer

Keywords

  • Cytotoxicity
  • Lecithin
  • Magnetic core microsphere
  • Poly(D, L-lactide-co-glycolic acid)
  • Targeted drug delivery

Cite this

Ayyanaar, Srinivasan ; Kesavan, Mookkandi Palsamy ; Balachandran, Chandrasekar ; Rasala, Swetha ; Rameshkumar, Perumal ; Aoki, Shin ; Rajesh, Jegathalaprathaban ; Webster, Thomas J. ; Rajagopal, Gurusamy. / Iron oxide nanoparticle core-shell magnetic microspheres : Applications toward targeted drug delivery. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2020 ; Vol. 24.
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Ayyanaar, S, Kesavan, MP, Balachandran, C, Rasala, S, Rameshkumar, P, Aoki, S, Rajesh, J, Webster, TJ & Rajagopal, G 2020, 'Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 24, 102134. https://doi.org/10.1016/j.nano.2019.102134

Iron oxide nanoparticle core-shell magnetic microspheres : Applications toward targeted drug delivery. / Ayyanaar, Srinivasan; Kesavan, Mookkandi Palsamy; Balachandran, Chandrasekar; Rasala, Swetha; Rameshkumar, Perumal; Aoki, Shin; Rajesh, Jegathalaprathaban; Webster, Thomas J.; Rajagopal, Gurusamy.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 24, 102134, 02.2020.

Research output: Contribution to journalArticle

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AU - Kesavan, Mookkandi Palsamy

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AU - Rasala, Swetha

AU - Rameshkumar, Perumal

AU - Aoki, Shin

AU - Rajesh, Jegathalaprathaban

AU - Webster, Thomas J.

AU - Rajagopal, Gurusamy

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