TY - JOUR
T1 - Iron oxide nanoparticle core-shell magnetic microspheres
T2 - Applications toward targeted drug delivery
AU - Ayyanaar, Srinivasan
AU - Kesavan, Mookkandi Palsamy
AU - Balachandran, Chandrasekar
AU - Rasala, Swetha
AU - Rameshkumar, Perumal
AU - Aoki, Shin
AU - Rajesh, Jegathalaprathaban
AU - Webster, Thomas J.
AU - Rajagopal, Gurusamy
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/2
Y1 - 2020/2
N2 - This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.
AB - This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.
KW - Cytotoxicity
KW - Lecithin
KW - Magnetic core microsphere
KW - Poly(D, L-lactide-co-glycolic acid)
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85077758460&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2019.102134
DO - 10.1016/j.nano.2019.102134
M3 - Article
C2 - 31830615
AN - SCOPUS:85077758460
SN - 1549-9634
VL - 24
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102134
ER -