Interleukin-1β abrogates long-term depression of hippocampal CA1 synaptic transmission

Yuji Ikegaya, Isabelle Delcroix, Yoichiro Iwakura, Norio Matsuki, Nobuyoshi Nishiyama

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Although interleukin-1β (IL-1β) is well known to modulate synaptic transmission and plasticity of the hippocampus, no study has yet evaluated how this cytokine affects long-term depression (LTD), one of the major forms of hippocampal synaptic plasticity. Here we report that at Schaffer collateral-CA1 synapses, bath application of IL-1β induces a long-lasting decrease in synaptic strength in intact slices, but not in disinhibited slices in the presence of bicuculline, a γ-aminobutyric acid receptor antagonist. The IL-1β-induced synaptic depression efficiently foreclosed the subsequent induction of LTD in response to a 1-Hz tetanus and, conversely, it was also prevented by preexisting LTD. These results suggest that IL-1β-induced, persistent depression of synaptic efficacy is required for GABAergic activation and shares, at least in part, a common cellular mechanism for LTD.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalSynapse
Volume47
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003

Keywords

  • Cytokine
  • Hippocampus synaptic plasticity
  • Interleukin
  • Knockout mouse
  • Long-term potentiation
  • Lymphocyte

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