Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes

D. P. Potaczek; Q. H. Wang; M. Sanak; T. Tokura; H. Matsuda; S. Dziedzina; N. Nakano; M. Hara; H. Ogawa; A. Szczeklik; K. Okumura; C. Nishiyama

doi:10.1111/j.1399-0039.2009.01360.x

Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes

D. P. Potaczek, Q. H. Wang, M. Sanak, T. Tokura, H. Matsuda, S. Dziedzina, N. Nakano, M. Hara, H. Ogawa, A. Szczeklik, K. Okumura, C. Nishiyama

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype-phenotype associations previously observed for some rather non-functional FCER2 variants.

Original language	English
Pages (from-to)	534-538
Number of pages	5
Journal	Tissue Antigens
Volume	74
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0039.2009.01360.x
Publication status	Published - Dec 2009

Keywords

FCER2
Haplotype
Polymorphism
Sp1
Sp3

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10.1111/j.1399-0039.2009.01360.x

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abstract = "Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype-phenotype associations previously observed for some rather non-functional FCER2 variants.",

keywords = "FCER2, Haplotype, Polymorphism, Sp1, Sp3",

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T1 - Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes

AU - Potaczek, D. P.

AU - Wang, Q. H.

AU - Sanak, M.

AU - Tokura, T.

AU - Matsuda, H.

AU - Dziedzina, S.

AU - Nakano, N.

AU - Hara, M.

AU - Ogawa, H.

AU - Szczeklik, A.

AU - Okumura, K.

AU - Nishiyama, C.

PY - 2009/12

Y1 - 2009/12

N2 - Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype-phenotype associations previously observed for some rather non-functional FCER2 variants.

AB - Low-affinity IgE receptor gene (FCER2) rs3760687 polymorphism was found to be associated with differential binding affinity of transcription factors Sp1 and Sp3 leading to altered transcriptional activity. Haplotypic interaction of functional FCER2 polymorphisms (rs28364072, rs2228137 and rs3760687) might potentially provide a background for genotype-phenotype associations previously observed for some rather non-functional FCER2 variants.

KW - FCER2

KW - Haplotype

KW - Polymorphism

KW - Sp1

KW - Sp3

UR - http://www.scopus.com/inward/record.url?scp=70449336475&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0039.2009.01360.x

DO - 10.1111/j.1399-0039.2009.01360.x

M3 - Article

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AN - SCOPUS:70449336475

SN - 0001-2815

VL - 74

SP - 534

EP - 538

JO - Tissue Antigens

JF - Tissue Antigens

IS - 6

ER -

Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes

Abstract

Keywords

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