Interaction between Hydrophilic Ionic Liquid and Phospholipid/Cholesterol Mixed Film

Kotaro Kaneko, Aki Nakazato, Akihiro Ishikawa, Nobuhiro Kaneko, Akira Yashita, Masaaki Akamatsu, Kenichi Sakai, Hideki Sakai

Research output: Contribution to journalArticlepeer-review


Surface pressure (π)-area (A) isotherms were studied to analyze the interactions between a hydrophilic ionic liquid (IL) (ethyl(2-hydroxyethyl)dimethylammonium methanesulfonate) and a pure dipalmitoylphosphatidylcholine (DPPC) film or a DPPC-cholesterol mixed film. When the hydrophilic IL was added to an underlayer solution, the isotherm shifted toward higher areas. Intriguingly, when the hydrophilic IL was added, the packing of the film materials became loose and the elastic modulus decreased, resulting in increased flexibility. This phenomenon was most evident under a cholesterol mole fraction of 0.2. This composition resembles that of cell membranes, which typically comprise phospholipids and cholesterol, suggesting that this hydrophilic IL may be able to interact significantly with biological membranes.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalJournal of oleo science
Issue number1
Publication statusPublished - 2022


  • Cholesterol
  • Fluorescence anisotropy
  • Hydrophilic ionic liquid
  • Phospholipid
  • Surface pressure-area (π-A) isotherm


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