Influence of Physiological Media on over-1000nm NIR Fluorescent DSPE-PEG Micelles for Bio-imaging

Thi Kim Dung Doan, Masakazu Umezawa, Hisanori Kobayashi, Atsushi Oshima, Kazuno Ikeda, Kyohei Okubo, Masao Kamimura, Kohei Soga

Research output: Contribution to journalArticlepeer-review

Abstract

Fluorescence imaging in the over-thousand nanometer (OTN-) near-infrared (NIR) wavelength region is an emerging technique for real-time bioimaging. OTN-NIR probes are made from micellar nanoparticles encapsulating IR-1061 dye in the core of poly(ethylene glycol) (PEG) phospholipid (PL), such as 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)- N-[methoxy PEG] micelles. The property investigation revealed that the probe is less stable in albumin and PBS while remaining unchanged in water and saline. The results are critical for applying OTN-NIR probe from DSPE-PEG micelles in physiological environments.

Original languageEnglish
Pages (from-to)208-211
Number of pages4
JournalChemistry Letters
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Bioimaging
  • IR-1061
  • OTN-NIR

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