Hydroxyapatite formation on CaSiO3 ceramics in protein containing system

Kiyoshi Okada, Punnama Siriphannon, Yoshikazu Kameshima, Atsuo Yasumori, Shigeo Hayashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

α-CaSiO3 ceramics with a nominal composition of CaO 46.0, SiO2 54.0, and Na2O 0.4 wt% were soaked in two different solutions, simulated body fluid (SBF) and α-minimum essential medium (α-MEM), to study the effect of protein on the formation of hydroxyapatite (HA). The SBF solution contained the same inorganic salts as in the human blood plasma, while the α-MEM solution contained both inorganic salts and various proteins. Both soaking systems were maintained at 36.5°C and a flow rate of about 40 ml/day for various periods of times. A complete coating of HA formed on the surface of the α-CaSiO3 ceramics in both solutions, but with different formation behavior and microstructure. The HA formed in the α-MEM system had ball-like particle morphology with a smaller particle size than the material formed in the SBF system. Cristobalite and/or unknown silicate phase coprecipitate with the HA in the α-MEM system but not in SBF. The HA layer formed on the ceramic surface achieved a thickness of about 80 and 93 μm after 20 days soaking in SBF and α-MEM solutions, respectively. The presence of protein in the α-MEM solution was considered to effect the microstructure of HA and possibly enhanced HA precipitation on the α-CaSiO3 ceramic.

Original languageEnglish
Pages (from-to)1551-1554
Number of pages4
JournalKey Engineering Materials
Issue number213 PART 3
Publication statusPublished - 1 Dec 2001

Keywords

  • α-casio ceramics
  • Bioactive materials
  • Hydroxyapatite
  • Protein

Cite this

Okada, K., Siriphannon, P., Kameshima, Y., Yasumori, A., & Hayashi, S. (2001). Hydroxyapatite formation on CaSiO3 ceramics in protein containing system. Key Engineering Materials, (213 PART 3), 1551-1554.