High-performance liquid chromatography mass spectrometry of gold and alloy clusters protected by hydrophilic thiolates

Yoshiki Niihori, Daisuke Shima, Kana Yoshida, Kota Hamada, Lakshmi V. Nair, Sakiat Hossain, Wataru Kurashige, Yuichi Negishi

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18 Citations (Scopus)

Abstract

In this work, we found two hydrophilic interaction liquid chromatography (HILIC) columns for high-performance liquid chromatography (HPLC) suitable for the high-resolution separation of hydrophilic metal clusters. The mass distributions of the product mixtures of hydrophilic metal clusters were evaluated via HPLC mass spectrometry (LC/MS) using these HILIC columns. Consequently, we observed multiple clusters that had not been previously reported for glutathionate (SG)-protected gold clusters (Aun(SG)m). Additionally, we demonstrated that Aun-xMx(SG)m alloy clusters (M = Ag, Cu, or Pd) in which part of the Au in the Aun(SG)m cluster is replaced by a heteroelement can be synthesized, similar to the case of hydrophobic alloy clusters. It is easy to evaluate the mass distributions of hydrophilic metal clusters using this method. Thus, remarkable progress in the synthesis techniques of hydrophilic metal clusters through the use of this method is anticipated, as is the situation for hydrophobic metal clusters.

Original languageEnglish
Pages (from-to)1641-1649
Number of pages9
JournalNanoscale
Volume10
Issue number4
DOIs
Publication statusPublished - 28 Jan 2018

Cite this

Niihori, Y., Shima, D., Yoshida, K., Hamada, K., Nair, L. V., Hossain, S., Kurashige, W., & Negishi, Y. (2018). High-performance liquid chromatography mass spectrometry of gold and alloy clusters protected by hydrophilic thiolates. Nanoscale, 10(4), 1641-1649. https://doi.org/10.1039/c7nr07840d