Hedgehog signaling for urogenital organogenesis and prostate cancer: An implication for the epithelial–mesenchyme interaction (EMI)

Taiju Hyuga, Mellissa Alcantara, Daiki Kajioka, Ryuma Haraguchi, Kentaro Suzuki, Shinichi Miyagawa, Yoshiyuki Kojima, Yutaro Hayashi, Gen Yamada

Research output: Contribution to journalReview article

Abstract

Hedgehog (Hh) signaling is an essential growth factor signaling pathway especially in the regulation of epithelial–mesenchymal interactions (EMI) during the development of the urogenital organs such as the bladder and the external genitalia (EXG). The Hh ligands are often expressed in the epithelia, affecting the surrounding mesenchyme, and thus constituting a form of paracrine signaling. The development of the urogenital organ, therefore, provides an intriguing opportunity to study EMI and its relationship with other pathways, such as hormonal signaling. Cellular interactions of prostate cancer (PCa) with its neighboring tissue is also noteworthy. The local microenvironment, including the bone metastatic site, can release cellular signals which can affect the malignant tumors, and vice versa. Thus, it is necessary to compare possible similarities and divergences in Hh signaling functions and its interaction with other local growth factors, such as BMP (bone morphogenetic protein) between organogenesis and tumorigenesis. Additionally, this review will discuss two pertinent research aspects of Hh signaling: (1) the potential signaling crosstalk between Hh and androgen signaling; and (2) the effect of signaling between the epithelia and the mesenchyme on the status of the basement membrane with extracellular matrix structures located on the epithelial–mesenchymal interface.

Original languageEnglish
Article number58
JournalInternational journal of molecular sciences
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

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Urogenital Neoplasms
Organogenesis
Mesoderm
Prostatic Neoplasms
Intercellular Signaling Peptides and Proteins
Epithelium
cancer
Paracrine Communication
Bone Morphogenetic Proteins
Genitalia
epithelium
Basement Membrane
organs
bones
Androgens
Extracellular Matrix
Carcinogenesis
Urinary Bladder
interactions
Ligands

Keywords

  • Androgen
  • Basement membrane
  • Bone morphogenetic protein
  • Epithelial
  • External genitalia
  • Hedgehog
  • Mesenchymal interaction (EMI)
  • Prostate cancer

Cite this

Hyuga, Taiju ; Alcantara, Mellissa ; Kajioka, Daiki ; Haraguchi, Ryuma ; Suzuki, Kentaro ; Miyagawa, Shinichi ; Kojima, Yoshiyuki ; Hayashi, Yutaro ; Yamada, Gen. / Hedgehog signaling for urogenital organogenesis and prostate cancer : An implication for the epithelial–mesenchyme interaction (EMI). In: International journal of molecular sciences. 2020 ; Vol. 21, No. 1.
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abstract = "Hedgehog (Hh) signaling is an essential growth factor signaling pathway especially in the regulation of epithelial–mesenchymal interactions (EMI) during the development of the urogenital organs such as the bladder and the external genitalia (EXG). The Hh ligands are often expressed in the epithelia, affecting the surrounding mesenchyme, and thus constituting a form of paracrine signaling. The development of the urogenital organ, therefore, provides an intriguing opportunity to study EMI and its relationship with other pathways, such as hormonal signaling. Cellular interactions of prostate cancer (PCa) with its neighboring tissue is also noteworthy. The local microenvironment, including the bone metastatic site, can release cellular signals which can affect the malignant tumors, and vice versa. Thus, it is necessary to compare possible similarities and divergences in Hh signaling functions and its interaction with other local growth factors, such as BMP (bone morphogenetic protein) between organogenesis and tumorigenesis. Additionally, this review will discuss two pertinent research aspects of Hh signaling: (1) the potential signaling crosstalk between Hh and androgen signaling; and (2) the effect of signaling between the epithelia and the mesenchyme on the status of the basement membrane with extracellular matrix structures located on the epithelial–mesenchymal interface.",
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Hedgehog signaling for urogenital organogenesis and prostate cancer : An implication for the epithelial–mesenchyme interaction (EMI). / Hyuga, Taiju; Alcantara, Mellissa; Kajioka, Daiki; Haraguchi, Ryuma; Suzuki, Kentaro; Miyagawa, Shinichi; Kojima, Yoshiyuki; Hayashi, Yutaro; Yamada, Gen.

In: International journal of molecular sciences, Vol. 21, No. 1, 58, 01.01.2020.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Hedgehog signaling for urogenital organogenesis and prostate cancer

T2 - An implication for the epithelial–mesenchyme interaction (EMI)

AU - Hyuga, Taiju

AU - Alcantara, Mellissa

AU - Kajioka, Daiki

AU - Haraguchi, Ryuma

AU - Suzuki, Kentaro

AU - Miyagawa, Shinichi

AU - Kojima, Yoshiyuki

AU - Hayashi, Yutaro

AU - Yamada, Gen

PY - 2020/1/1

Y1 - 2020/1/1

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AB - Hedgehog (Hh) signaling is an essential growth factor signaling pathway especially in the regulation of epithelial–mesenchymal interactions (EMI) during the development of the urogenital organs such as the bladder and the external genitalia (EXG). The Hh ligands are often expressed in the epithelia, affecting the surrounding mesenchyme, and thus constituting a form of paracrine signaling. The development of the urogenital organ, therefore, provides an intriguing opportunity to study EMI and its relationship with other pathways, such as hormonal signaling. Cellular interactions of prostate cancer (PCa) with its neighboring tissue is also noteworthy. The local microenvironment, including the bone metastatic site, can release cellular signals which can affect the malignant tumors, and vice versa. Thus, it is necessary to compare possible similarities and divergences in Hh signaling functions and its interaction with other local growth factors, such as BMP (bone morphogenetic protein) between organogenesis and tumorigenesis. Additionally, this review will discuss two pertinent research aspects of Hh signaling: (1) the potential signaling crosstalk between Hh and androgen signaling; and (2) the effect of signaling between the epithelia and the mesenchyme on the status of the basement membrane with extracellular matrix structures located on the epithelial–mesenchymal interface.

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KW - Basement membrane

KW - Bone morphogenetic protein

KW - Epithelial

KW - External genitalia

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KW - Mesenchymal interaction (EMI)

KW - Prostate cancer

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