Gonadal differentiation in reptiles exhibiting environmental sex determination

Satomi Kohno, Benjamin B. Parrott, Ryohei Yatsu, Shinichi Miyagawa, Brandon C. Moore, Taisen Iguchi, Louis J. Guillette

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14 Citations (Scopus)

Abstract

As temperature-dependent sex determination (TSD) and homozygote or heterozygote genetic sex determination (GSD) exist in multiple reptilian taxa, they represent sex determination systems that have emerged de novo. Current investigations have revealed that the genetic mechanisms used by various reptilian species are similar to those used by other vertebrates. However, the recent completion or near completion of various reptilian genome projects suggests that new studies examining related species with and without TSD could begin to provide additional insight into the evolution of TSD and GSD in vertebrate ancestors. Major questions still remain concerning germ cell migration and specification, the differentiation of gonadal accessory cells, such as the Sertoli cells and granulosa cells of the developing testis and ovary, respectively, and the mechanisms by which gene expression is regulated during TSD events. Further, reptilian sentinels and their mechanisms of gonadogenesis will likely remain important indicator species for environmental health. Thus, ongoing and new investigations need to tie molecular information to gonadal morphogenesis and function in reptiles. Such data will not only provide important information for an understanding of the evolution of these phenomena in vertebrates, but could also provide an important understanding of the health of the environment around us.

Original languageEnglish
Pages (from-to)208-226
Number of pages19
JournalSexual Development
Volume8
Issue number5
DOIs
Publication statusPublished - 1 Sep 2014

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Keywords

  • CYP19 aromatase
  • DNA methylation
  • Endocrine-disrupting contaminants
  • Estrogen signal
  • Germ cell migration
  • Germ cell specification
  • Oogenesis
  • Spermatogenesis
  • Temperature-dependent sex determination

Cite this

Kohno, S., Parrott, B. B., Yatsu, R., Miyagawa, S., Moore, B. C., Iguchi, T., & Guillette, L. J. (2014). Gonadal differentiation in reptiles exhibiting environmental sex determination. Sexual Development, 8(5), 208-226. https://doi.org/10.1159/000358892