Gold nanorods functionalized with self-assemb led glycopolymers for ultrasensitive detection of proteins

Hidenori Otsuka; Yuki Muramatsu; Daisuke Matsukuma

doi:10.1246/cl.140943

Gold nanorods functionalized with self-assemb led glycopolymers for ultrasensitive detection of proteins

Hidenori Otsuka, Yuki Muramatsu, Daisuke Matsukuma

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

New, stable, and glyoco-derivatized gold nanorods (GNRs) were prepared using developed amphiphilic block glycopolymers poly[(lactose)_m-b-(pyridine)_n] to engineer self-organized, densely packed g lycopolymeric recognition layers and generate a multivalent binding cav ity onto the gold surface. We report a rapid and u ltrasensitive biosensing for the weak affinity of protein-carbohydrate binding employing a combination of the longitudinal SPR of GNRs and the cluster glycoside effect. Thus, a very small amount of lectin (100 pgmL^-1 = 8.3 × 10^-13 M) was detected by the aggregation of GNRs.

Original language	English
Pages (from-to)	132-134
Number of pages	3
Journal	Chemistry Letters
Volume	44
Issue number	2
DOIs	https://doi.org/10.1246/cl.140943
Publication status	Published - 2015

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title = "Gold nanorods functionalized with self-assemb led glycopolymers for ultrasensitive detection of proteins",

abstract = "New, stable, and glyoco-derivatized gold nanorods (GNRs) were prepared using developed amphiphilic block glycopolymers poly[(lactose)m-b-(pyridine)n] to engineer self-organized, densely packed g lycopolymeric recognition layers and generate a multivalent binding cav ity onto the gold surface. We report a rapid and u ltrasensitive biosensing for the weak affinity of protein-carbohydrate binding employing a combination of the longitudinal SPR of GNRs and the cluster glycoside effect. Thus, a very small amount of lectin (100 pgmL-1 = 8.3 × 10-13 M) was detected by the aggregation of GNRs.",

author = "Hidenori Otsuka and Yuki Muramatsu and Daisuke Matsukuma",

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journal = "Chemistry Letters",

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AU - Otsuka, Hidenori

AU - Muramatsu, Yuki

AU - Matsukuma, Daisuke

PY - 2015

Y1 - 2015

N2 - New, stable, and glyoco-derivatized gold nanorods (GNRs) were prepared using developed amphiphilic block glycopolymers poly[(lactose)m-b-(pyridine)n] to engineer self-organized, densely packed g lycopolymeric recognition layers and generate a multivalent binding cav ity onto the gold surface. We report a rapid and u ltrasensitive biosensing for the weak affinity of protein-carbohydrate binding employing a combination of the longitudinal SPR of GNRs and the cluster glycoside effect. Thus, a very small amount of lectin (100 pgmL-1 = 8.3 × 10-13 M) was detected by the aggregation of GNRs.

AB - New, stable, and glyoco-derivatized gold nanorods (GNRs) were prepared using developed amphiphilic block glycopolymers poly[(lactose)m-b-(pyridine)n] to engineer self-organized, densely packed g lycopolymeric recognition layers and generate a multivalent binding cav ity onto the gold surface. We report a rapid and u ltrasensitive biosensing for the weak affinity of protein-carbohydrate binding employing a combination of the longitudinal SPR of GNRs and the cluster glycoside effect. Thus, a very small amount of lectin (100 pgmL-1 = 8.3 × 10-13 M) was detected by the aggregation of GNRs.

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VL - 44

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JO - Chemistry Letters

JF - Chemistry Letters

IS - 2

ER -

Gold nanorods functionalized with self-assemb led glycopolymers for ultrasensitive detection of proteins

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