Gene transduction by sonoporation

Sho Ohta, Kentaro Suzuki, Yukiko Ogino, Shinichi Miyagawa, Aki Murashima, Daisuke Matsumaru, Gen Yamada

Research output: Contribution to journalShort survey

28 Citations (Scopus)


Gene transduction technologies are essential tools for understanding of gene functions or gene cascades underlying embryogenesis. In this review, we introduce a gene transduction method using microbubble and ultrasound (hereafter referred to as sonoporation). Sonoporation is carried out with relatively simple procedures and easily transduces genes into mesenchymal cells without significant damage to target tissues. Therefore, sonoporation is effective for gene transduction to study the molecular mechanisms of morphogenesis.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalDevelopment Growth and Differentiation
Issue number6
Publication statusPublished - 1 Aug 2008



  • Gene transduction chick
  • Limb bud
  • Microbubble
  • Sonoporation
  • Ultrasound

Cite this

Ohta, S., Suzuki, K., Ogino, Y., Miyagawa, S., Murashima, A., Matsumaru, D., & Yamada, G. (2008). Gene transduction by sonoporation. Development Growth and Differentiation, 50(6), 517-520.