FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

Y. Niwa; D. P. Potaczek; S. Kanada; A. Takagi; N. Shimokawa; T. Lto; K. Mitsuishi; Y. Okubo; M. Tajima; A. Hobo; W. Ng; R. Tsuboi; S. Ikeda; H. Ogawa; K. Okumura; C. Nishiyama

doi:10.1111/j.1744-313X.2010.00901.x

FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

Y. Niwa, D. P. Potaczek, S. Kanada, A. Takagi, N. Shimokawa, T. Lto, K. Mitsuishi, Y. Okubo, M. Tajima, A. Hobo, W. Ng, R. Tsuboi, S. Ikeda, H. Ogawa, K. Okumura, C. Nishiyama

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Two promoter polymorphisms of the high-affinity IgE receptor a-subunit (FceRIa) gene (FCER1A), )66T>C (rs2251746) and )315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the )315CT?TT genotype tended to have higher total serum IgE levels, while the proportion of )315CT?TT genotype or the )315T allele was significantly higher in those with highly elevated total serum IgE concentrations.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	International Journal of Immunogenetics
Volume	37
Issue number	2
DOIs	https://doi.org/10.1111/j.1744-313X.2010.00901.x
Publication status	Published - Apr 2010

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10.1111/j.1744-313X.2010.00901.x

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Niwa, Y., Potaczek, D. P., Kanada, S., Takagi, A., Shimokawa, N., Lto, T., Mitsuishi, K., Okubo, Y., Tajima, M., Hobo, A., Ng, W., Tsuboi, R., Ikeda, S., Ogawa, H., Okumura, K., & Nishiyama, C. (2010). FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. International Journal of Immunogenetics, 37(2), 139-141. https://doi.org/10.1111/j.1744-313X.2010.00901.x

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title = "FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients",

abstract = "Two promoter polymorphisms of the high-affinity IgE receptor a-subunit (FceRIa) gene (FCER1A), )66T>C (rs2251746) and )315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the )315CT?TT genotype tended to have higher total serum IgE levels, while the proportion of )315CT?TT genotype or the )315T allele was significantly higher in those with highly elevated total serum IgE concentrations.",

author = "Y. Niwa and Potaczek, {D. P.} and S. Kanada and A. Takagi and N. Shimokawa and T. Lto and K. Mitsuishi and Y. Okubo and M. Tajima and A. Hobo and W. Ng and R. Tsuboi and S. Ikeda and H. Ogawa and K. Okumura and C. Nishiyama",

year = "2010",

month = apr,

doi = "10.1111/j.1744-313X.2010.00901.x",

language = "English",

volume = "37",

pages = "139--141",

journal = "International Journal of Immunogenetics",

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Niwa, Y, Potaczek, DP, Kanada, S, Takagi, A, Shimokawa, N, Lto, T, Mitsuishi, K, Okubo, Y, Tajima, M, Hobo, A, Ng, W, Tsuboi, R, Ikeda, S, Ogawa, H, Okumura, K & Nishiyama, C 2010, 'FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients', International Journal of Immunogenetics, vol. 37, no. 2, pp. 139-141. https://doi.org/10.1111/j.1744-313X.2010.00901.x

TY - JOUR

T1 - FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

AU - Niwa, Y.

AU - Potaczek, D. P.

AU - Kanada, S.

AU - Takagi, A.

AU - Shimokawa, N.

AU - Lto, T.

AU - Mitsuishi, K.

AU - Okubo, Y.

AU - Tajima, M.

AU - Hobo, A.

AU - Ng, W.

AU - Tsuboi, R.

AU - Ikeda, S.

AU - Ogawa, H.

AU - Okumura, K.

AU - Nishiyama, C.

PY - 2010/4

Y1 - 2010/4

N2 - Two promoter polymorphisms of the high-affinity IgE receptor a-subunit (FceRIa) gene (FCER1A), )66T>C (rs2251746) and )315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the )315CT?TT genotype tended to have higher total serum IgE levels, while the proportion of )315CT?TT genotype or the )315T allele was significantly higher in those with highly elevated total serum IgE concentrations.

AB - Two promoter polymorphisms of the high-affinity IgE receptor a-subunit (FceRIa) gene (FCER1A), )66T>C (rs2251746) and )315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the )315CT?TT genotype tended to have higher total serum IgE levels, while the proportion of )315CT?TT genotype or the )315T allele was significantly higher in those with highly elevated total serum IgE concentrations.

UR - http://www.scopus.com/inward/record.url?scp=77953568716&partnerID=8YFLogxK

U2 - 10.1111/j.1744-313X.2010.00901.x

DO - 10.1111/j.1744-313X.2010.00901.x

M3 - Article

C2 - 20141544

AN - SCOPUS:77953568716

SN - 1744-3121

VL - 37

SP - 139

EP - 141

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 2

ER -

FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients

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