Enantioselective synthesis induced by chiral organic-inorganic hybrid silsesquioxane in conjunction with asymmetric autocatalysis

Tsuneomi Kawasaki, Keisuke Ishikawa, Hiromitsu Sekibata, Itaru Sato, Kenso Soai

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

5-Pyrimidyl alkanol with up to 96% ee was formed using chiral organic-inorganic hybrid silsesquioxane in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, in conjunction with asymmetric autocatalysis.

Original languageEnglish
Pages (from-to)7939-7941
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number42
DOIs
Publication statusPublished - 11 Oct 2004

Keywords

  • Asymmetric autocatalysis
  • Asymmetric induction
  • Asymmetric synthesis
  • Chiral hybrid silsesquioxane

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