Enantioselective nucleophilic substitution of a 6,6-bicyclic dienyl acetate by palladium-chiral phosphine catalyst

Isao Shimizu, Yoshiyuki Matsumoto, Masahiro Nishikawa, Tamotsu Kawahara, Akiharu Satake, Akio Yamamoto

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The enantioselective nucleophilic substitution of (±)-2β-acetoxy-4aβ-methyl-2,3,4,4a,5,6-hexahydronaphthalene with dimethyl malonate anion was performed in the presence of palladium-chiral ligand catalysts to give optically active 2-di(methoxycarbonyl)methyl-4a-methyl-2,3,4,4a,5,6-hexahydronaphthalenes.

Original languageEnglish
Pages (from-to)983-984
Number of pages2
JournalChemistry Letters
Issue number10
Publication statusPublished - 1 Jan 1998

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