TY - JOUR
T1 - Effects of polymer molecular weight on curcumin amorphous solid dispersion; at-line monitoring system based on attenuated total reflectance mid-infrared and near-infrared spectroscopy
AU - Mai, Nguyen Ngoc Sao
AU - Otsuka, Yuta
AU - Goto, Satoru
AU - Kawano, Yayoi
AU - Hanawa, Takehisa
N1 - Funding Information:
This work was partly supported by Japan Society for the Promotion of Science KAKENHI Grant number 20K15976 .
Funding Information:
The first author is grateful to the Ministry of Education, Culture, Sport, Science, and Technology Japan for a PhD scholarship.
PY - 2021/2
Y1 - 2021/2
N2 - The aim of this study was to investigate the effects of the molecular weight (Mw) of hydroxypropyl cellulose (HPC) and grinding duration on solid dispersions (SDs) formation and their characteristics. In this study, ternary amorphous SD systems containing curcumin (CUR), HPC, and sodium dodecyl sulfate (SDS) were developed using the milling method and characterized their physicochemical and mechanochemical properties. After 120-min grinding, the particle size reduced to under 1 μm and the GMs totally transformed into amorphous phase. The release behavior of CUR depended on the grade of HPCs due to their Mw and corresponding viscosity. During the SD formation process, the grinding time and Mw of HPC could be monitored by analyzing data obtained from MIR and NIR spectra based on chemometrics. There were two steps in SD formation: (1) simple dispersion with grinding time under 30 min and (2) random dispersion of mixtures with grinding time from 30 to 120 min. The HPC-M (700,000 Da) resulted in more effectively forming SD systems.
AB - The aim of this study was to investigate the effects of the molecular weight (Mw) of hydroxypropyl cellulose (HPC) and grinding duration on solid dispersions (SDs) formation and their characteristics. In this study, ternary amorphous SD systems containing curcumin (CUR), HPC, and sodium dodecyl sulfate (SDS) were developed using the milling method and characterized their physicochemical and mechanochemical properties. After 120-min grinding, the particle size reduced to under 1 μm and the GMs totally transformed into amorphous phase. The release behavior of CUR depended on the grade of HPCs due to their Mw and corresponding viscosity. During the SD formation process, the grinding time and Mw of HPC could be monitored by analyzing data obtained from MIR and NIR spectra based on chemometrics. There were two steps in SD formation: (1) simple dispersion with grinding time under 30 min and (2) random dispersion of mixtures with grinding time from 30 to 120 min. The HPC-M (700,000 Da) resulted in more effectively forming SD systems.
KW - Amorphous solid dispersions
KW - At-line monitor
KW - Middle-infrared spectroscopy
KW - Molecular weight
KW - Multivariate analysis
KW - Near-infrared spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85098157732&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2020.102278
DO - 10.1016/j.jddst.2020.102278
M3 - Article
AN - SCOPUS:85098157732
VL - 61
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
M1 - 102278
ER -