Effect of low-voltage pulse on cell elimination

Hidenori Otsuka; Saya Okimura; Masako Nagamura; Daisuke Matsukuma; Koichi Kutsuzawa; Naoki Matsuda; Tatsuro Nakashima; Hirotaka Okabe

doi:10.1246/cl.2012.1636

Effect of low-voltage pulse on cell elimination

Hidenori Otsuka, Saya Okimura, Masako Nagamura, Daisuke Matsukuma, Koichi Kutsuzawa, Naoki Matsuda, Tatsuro Nakashima, Hirotaka Okabe

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

The low electric field application to HeLa cells adhered to electrodes was studied to induce cell death effectively. The lowvoltage pulse applied to the electrode was generated with charge and discharge by an originally made circuit. The unique characteristics in this experiment is the charge flow between electrodes, and it causes direct attack of the ions to the cell membrane, leading to complete cell elimination. Viability of cells appreciably decreased with increase in discharge time at a quite low 3Vcm^-1 that has not been reported to date.

Original language	English
Pages (from-to)	1636-1638
Number of pages	3
Journal	Chemistry Letters
Volume	41
Issue number	12
DOIs	https://doi.org/10.1246/cl.2012.1636
Publication status	Published - 2012

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title = "Effect of low-voltage pulse on cell elimination",

abstract = "The low electric field application to HeLa cells adhered to electrodes was studied to induce cell death effectively. The lowvoltage pulse applied to the electrode was generated with charge and discharge by an originally made circuit. The unique characteristics in this experiment is the charge flow between electrodes, and it causes direct attack of the ions to the cell membrane, leading to complete cell elimination. Viability of cells appreciably decreased with increase in discharge time at a quite low 3Vcm-1 that has not been reported to date.",

author = "Hidenori Otsuka and Saya Okimura and Masako Nagamura and Daisuke Matsukuma and Koichi Kutsuzawa and Naoki Matsuda and Tatsuro Nakashima and Hirotaka Okabe",

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AU - Otsuka, Hidenori

AU - Okimura, Saya

AU - Nagamura, Masako

AU - Matsukuma, Daisuke

AU - Kutsuzawa, Koichi

AU - Matsuda, Naoki

AU - Nakashima, Tatsuro

AU - Okabe, Hirotaka

PY - 2012

Y1 - 2012

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AB - The low electric field application to HeLa cells adhered to electrodes was studied to induce cell death effectively. The lowvoltage pulse applied to the electrode was generated with charge and discharge by an originally made circuit. The unique characteristics in this experiment is the charge flow between electrodes, and it causes direct attack of the ions to the cell membrane, leading to complete cell elimination. Viability of cells appreciably decreased with increase in discharge time at a quite low 3Vcm-1 that has not been reported to date.

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JO - Chemistry Letters

JF - Chemistry Letters

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Effect of low-voltage pulse on cell elimination

Abstract

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