Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389

Yoichi Hayakawa; Tomohiro Yoshida; Shoko Kimata; Kazuo Shin-ya

doi:10.1038/s41429-020-0356-8

Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389

Yoichi Hayakawa, Tomohiro Yoshida, Shoko Kimata, Kazuo Shin-ya

Department of Medicinal and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C₄₂H₇₀O₁₀ by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC₅₀ of 8.4 nM.

Original language	English
Pages (from-to)	76-79
Number of pages	4
Journal	Journal of Antibiotics
Volume	74
Issue number	1
DOIs	https://doi.org/10.1038/s41429-020-0356-8
Publication status	Published - Jan 2021

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title = "Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389",

abstract = "A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 8.4 nM.",

author = "Yoichi Hayakawa and Tomohiro Yoshida and Shoko Kimata and Kazuo Shin-ya",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1038/s41429-020-0356-8",

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AU - Yoshida, Tomohiro

AU - Kimata, Shoko

AU - Shin-ya, Kazuo

PY - 2021/1

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AB - A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 8.4 nM.

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