Dissolution of Water-insoluble Curcumin by Femtosecond-laser Ablation in the Presence of Cyclodextrins and Its Cytotoxic Bioactivity against Lung Cancer Cells

Daisuke Nakane; Tatsuaki Tagami; Tomohiko Inomata; Yuki Ichikawa; Akiko Nakada; Tetsuya Ozeki; Hideki Masuda

doi:10.1246/cl.160509

Dissolution of Water-insoluble Curcumin by Femtosecond-laser Ablation in the Presence of Cyclodextrins and Its Cytotoxic Bioactivity against Lung Cancer Cells

Daisuke Nakane, Tatsuaki Tagami, Tomohiko Inomata, Yuki Ichikawa, Akiko Nakada, Tetsuya Ozeki, Hideki Masuda

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Dissolution of water-insoluble curcumin at a high concentration (>100μM) is achieved by femtosecond-laser ablation in an aqueous solution containing cyclodextrin compounds at room temperature. The curcumin solution is freeze-dried to yield an orange powder, which isalso highlysoluble in water (ca. 1 mM). The dissolved curcumin compound has cytotoxic activity toward lung cancer cells.

Original language	English
Pages (from-to)	1072-1074
Number of pages	3
Journal	Chemistry Letters
Volume	45
Issue number	9
DOIs	https://doi.org/10.1246/cl.160509
Publication status	Published - 2016

Keywords

Anticancer effect
Curcumin
Cyclodextrin

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10.1246/cl.160509

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title = "Dissolution of Water-insoluble Curcumin by Femtosecond-laser Ablation in the Presence of Cyclodextrins and Its Cytotoxic Bioactivity against Lung Cancer Cells",

abstract = "Dissolution of water-insoluble curcumin at a high concentration (>100μM) is achieved by femtosecond-laser ablation in an aqueous solution containing cyclodextrin compounds at room temperature. The curcumin solution is freeze-dried to yield an orange powder, which isalso highlysoluble in water (ca. 1 mM). The dissolved curcumin compound has cytotoxic activity toward lung cancer cells.",

keywords = "Anticancer effect, Curcumin, Cyclodextrin",

author = "Daisuke Nakane and Tatsuaki Tagami and Tomohiko Inomata and Yuki Ichikawa and Akiko Nakada and Tetsuya Ozeki and Hideki Masuda",

note = "Publisher Copyright: {\textcopyright} 2016 The Chemical Society of Japan.",

year = "2016",

doi = "10.1246/cl.160509",

language = "English",

volume = "45",

pages = "1072--1074",

journal = "Chemistry Letters",

issn = "0366-7022",

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T1 - Dissolution of Water-insoluble Curcumin by Femtosecond-laser Ablation in the Presence of Cyclodextrins and Its Cytotoxic Bioactivity against Lung Cancer Cells

AU - Nakane, Daisuke

AU - Tagami, Tatsuaki

AU - Inomata, Tomohiko

AU - Ichikawa, Yuki

AU - Nakada, Akiko

AU - Ozeki, Tetsuya

AU - Masuda, Hideki

PY - 2016

Y1 - 2016

N2 - Dissolution of water-insoluble curcumin at a high concentration (>100μM) is achieved by femtosecond-laser ablation in an aqueous solution containing cyclodextrin compounds at room temperature. The curcumin solution is freeze-dried to yield an orange powder, which isalso highlysoluble in water (ca. 1 mM). The dissolved curcumin compound has cytotoxic activity toward lung cancer cells.

AB - Dissolution of water-insoluble curcumin at a high concentration (>100μM) is achieved by femtosecond-laser ablation in an aqueous solution containing cyclodextrin compounds at room temperature. The curcumin solution is freeze-dried to yield an orange powder, which isalso highlysoluble in water (ca. 1 mM). The dissolved curcumin compound has cytotoxic activity toward lung cancer cells.

KW - Anticancer effect

KW - Curcumin

KW - Cyclodextrin

UR - https://www.scopus.com/pages/publications/84986592834

U2 - 10.1246/cl.160509

DO - 10.1246/cl.160509

M3 - Article

AN - SCOPUS:84986592834

SN - 0366-7022

VL - 45

SP - 1072

EP - 1074

JO - Chemistry Letters

JF - Chemistry Letters

IS - 9

ER -

Dissolution of Water-insoluble Curcumin by Femtosecond-laser Ablation in the Presence of Cyclodextrins and Its Cytotoxic Bioactivity against Lung Cancer Cells

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