Directional coupler biosensor with molecularly imprinted polymer

Ken Uchiyamada, Kyohei Okubo, Kiyoshi Asakawa, Yuri Kamon, Yukiya Kitayama, Toshifumi Takeuchi, Hiroaki Suzuki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A microfabricated directional coupler (DC) was used for the label-free, real-time detection of proteins. As an alternative to biomolecules such as antibodies, molecularly imprinted polymer (MIP) was used. With human serum albumin (HSA) as a model analyte, distinct responses were observed. On the other hand, the sensor did not respond to bovine serum albumin (BSA). Also, with a nonimprinted polymer (NIP), no responses were observed for HSA. The MIP could be regenerated, and responses of the same sensor after three cycles of measurement and regeneration gave similar values.

Original languageEnglish
Pages (from-to)1009-1017
Number of pages9
JournalSensors and Materials
Issue number5
Publication statusPublished - 2018


  • Directional coupler
  • Human serum albumin (HSA)
  • Molecularly imprinted polymer (MIP)
  • Silicon nitride waveguide


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