TY - JOUR
T1 - Directional coupler biosensor with molecularly imprinted polymer
AU - Uchiyamada, Ken
AU - Okubo, Kyohei
AU - Asakawa, Kiyoshi
AU - Kamon, Yuri
AU - Kitayama, Yukiya
AU - Takeuchi, Toshifumi
AU - Suzuki, Hiroaki
N1 - Funding Information:
We thank Dr. Hirotaka Osato of National Institute of Material Science and Professor Edwin T. Carlen of University of Tsukuba for their suggestions and support. K. U. thanks the JSPS Research Fellowships for Young Scientists (Project No. 16J05520) for financial support. The devices were fabricated with the support of University of Tsukuba Nanotechnology Platform and the National Institute of Material Science Nanofabrication Platform.
Publisher Copyright:
© 2018 M Y U Scientific Publishing Division. All rights reserved.
PY - 2018
Y1 - 2018
N2 - A microfabricated directional coupler (DC) was used for the label-free, real-time detection of proteins. As an alternative to biomolecules such as antibodies, molecularly imprinted polymer (MIP) was used. With human serum albumin (HSA) as a model analyte, distinct responses were observed. On the other hand, the sensor did not respond to bovine serum albumin (BSA). Also, with a nonimprinted polymer (NIP), no responses were observed for HSA. The MIP could be regenerated, and responses of the same sensor after three cycles of measurement and regeneration gave similar values.
AB - A microfabricated directional coupler (DC) was used for the label-free, real-time detection of proteins. As an alternative to biomolecules such as antibodies, molecularly imprinted polymer (MIP) was used. With human serum albumin (HSA) as a model analyte, distinct responses were observed. On the other hand, the sensor did not respond to bovine serum albumin (BSA). Also, with a nonimprinted polymer (NIP), no responses were observed for HSA. The MIP could be regenerated, and responses of the same sensor after three cycles of measurement and regeneration gave similar values.
KW - Directional coupler
KW - Human serum albumin (HSA)
KW - Molecularly imprinted polymer (MIP)
KW - Silicon nitride waveguide
UR - http://www.scopus.com/inward/record.url?scp=85047110461&partnerID=8YFLogxK
U2 - 10.18494/SAM.2018.1815
DO - 10.18494/SAM.2018.1815
M3 - Article
AN - SCOPUS:85047110461
VL - 30
SP - 1009
EP - 1017
JO - Sensors and Materials
JF - Sensors and Materials
SN - 0914-4935
IS - 5
ER -