Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

Takunori Harada, Hiraku Matsuzaki, Ryohei Oyama, Takuma Takeuchi, Tomoaki Takei, Taisuke Ninomiya, Kouta Takami, Takanori Inoue, Hiroyasu Nishiguchi, Emi Hifumi, Hiroyuki Shinto, Hiromi Takahashi, Kazuo Umemura

Research output: Contribution to journalArticle

Abstract

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalPhotochemical and Photobiological Sciences
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

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