Creation of assembling structures of organic-inorganic vesicular nanocapsule "cerasome" triggered by electrostatic interactions

Mineo Hashizume, Takashi Terashima, Jun Ichi Kikuchi

Research output: Contribution to conferencePaper

Abstract

In this study, integrated assembly of Cerasome, an organic-inorganic vesicular nanohybrid, on DNA and other polymer templates in solution was investigated. Cationic Cerasomes assembled on DNA without losing their vesicular structure, whereas reference cationic vesicles fused together followed by assembling on DNA. The resultant Cerasome-DNA complexes could keep their assembled structure in acidic pH, indicating strong multivalent electrostatic interaction between Cerasome and DNA. The Cerasome also assembled on other negatively-charged polymers such as heparin or potassium polyvinyl sulfate, however, the fusion of Cerasome occurred in the case of these polymers. The experimental results showed that the molecular structure and concentration of polymer templates are critical for the construction of mulicellular assembly of Cerasome on ionic polymer templates.

Original languageEnglish
Number of pages1
Publication statusPublished - 1 Dec 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 25 May 200527 May 2005

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period25/05/0527/05/05

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Keywords

  • Cerasome
  • Electrostatic interaction
  • Integrated assembly
  • Multicellular model
  • Organic-inorganic nanohybrid

Cite this

Hashizume, M., Terashima, T., & Kikuchi, J. I. (2005). Creation of assembling structures of organic-inorganic vesicular nanocapsule "cerasome" triggered by electrostatic interactions. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.