Copper(II)-catalyzed oxidative N-nitrosation of secondary and tertiary amines with nitromethane under an oxygen atmosphere

Norio Sakai, Minoru Sasaki, Yohei Ogiwara

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15 Citations (Scopus)


The combination of a catalytic amount of Cu(OTf)2 and less than a stoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under an O2 atmosphere effectively promoted the N-nitrosation of both secondary aromatic/aliphatic amines and tertiary aromatic amines with nitromethane (CH3NO2) leading to the preparation of N-nitrosamine derivatives.

Original languageEnglish
Pages (from-to)11638-11641
Number of pages4
JournalChemical Communications
Issue number58
Publication statusPublished - 25 Jul 2015

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