TY - JOUR
T1 - Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone
T2 - Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding properties
AU - Rahman, K. N.Anees
AU - Haribabu, Jebiti
AU - Balachandran, Chandrasekar
AU - Bhuvanesh, Nattamai S.P.
AU - Karvembu, Ramasamy
AU - Sreekanth, Anandram
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017
Y1 - 2017
N2 - A new 3-acetylcoumarin thiosemicarbazone (AcTsc) and its copper(II) (1), nickel(II) (2) and zinc(II) (3) complexes were synthesized and characterized by elemental analysis, UV–Vis, FT-IR, 1H and 13C NMR/EPR and mass spectroscopic techniques. The molecular structure of AcTsc, and the complexes 1 and 3 was confirmed by single crystal X-ray crystallography. The interaction of the complexes (1–3) with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was explored using absorption and emission spectral methods, and viscosity measurement. The spectroscopic results clearly suggested that the complexes (1–3) interacted with CT-DNA through intercalative binding mode. In addition, all the complexes were subjected to cytotoxic studies against human liver carcinoma (HepG-2), lung carcinoma (A549), human leukemic monocyte lymphoma (U937) and lymphoblastoid multiple myeloma cells (IM-9). Complex 3 showed significant cytotoxicity against human liver carcinoma (HepG-2) and lymphoblastoid multiple myeloma (IM-9) cell lines with the IC50 value of 25 μg/mL.
AB - A new 3-acetylcoumarin thiosemicarbazone (AcTsc) and its copper(II) (1), nickel(II) (2) and zinc(II) (3) complexes were synthesized and characterized by elemental analysis, UV–Vis, FT-IR, 1H and 13C NMR/EPR and mass spectroscopic techniques. The molecular structure of AcTsc, and the complexes 1 and 3 was confirmed by single crystal X-ray crystallography. The interaction of the complexes (1–3) with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was explored using absorption and emission spectral methods, and viscosity measurement. The spectroscopic results clearly suggested that the complexes (1–3) interacted with CT-DNA through intercalative binding mode. In addition, all the complexes were subjected to cytotoxic studies against human liver carcinoma (HepG-2), lung carcinoma (A549), human leukemic monocyte lymphoma (U937) and lymphoblastoid multiple myeloma cells (IM-9). Complex 3 showed significant cytotoxicity against human liver carcinoma (HepG-2) and lymphoblastoid multiple myeloma (IM-9) cell lines with the IC50 value of 25 μg/mL.
KW - Copper(II)
KW - Cytotoxicity
KW - DNA/BSA interaction
KW - Nickel(II)
KW - Zinc(II)
UR - http://www.scopus.com/inward/record.url?scp=85024127596&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2017.06.044
DO - 10.1016/j.poly.2017.06.044
M3 - Article
AN - SCOPUS:85024127596
SN - 0277-5387
VL - 135
SP - 26
EP - 35
JO - Polyhedron
JF - Polyhedron
ER -