Contribution of fibroblasts cultured on 3D silica nonwoven fabrics to cocultured hepatocytes function

Hidenori Otsuka; Kohei Sasaki; Saya Okimura; Masako Nagamura; Rie Watanabe; Masaaki Kawabe

doi:10.1246/cl.130955

Contribution of fibroblasts cultured on 3D silica nonwoven fabrics to cocultured hepatocytes function

Hidenori Otsuka, Kohei Sasaki, Saya Okimura, Masako Nagamura, Rie Watanabe, Masaaki Kawabe

Department of Applied Chemistry

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7 Citations (Scopus)

Abstract

It is worth investigating heterotypic cell-cell interactions by mimicking their in vivo environment. In the present study, the mechanism of functional enhancement was investigated in a hepatocyte-fibroblast coculture with respect to the contributions of soluble factors. The enhanced hepatic functions through heterotypic interactions are effective by increasing fibroblast proliferation separately cocultured in 3D silica fabrics. The important roles of active soluble factors in heterotypic cell communications were suggested by this study using 3D proliferated tissues with satisfactory physiological morphologies in silica fabrics.

Original language	English
Pages (from-to)	343-345
Number of pages	3
Journal	Chemistry Letters
Volume	43
Issue number	3
DOIs	https://doi.org/10.1246/cl.130955
Publication status	Published - 2014

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AU - Otsuka, Hidenori

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AU - Nagamura, Masako

AU - Watanabe, Rie

AU - Kawabe, Masaaki

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AB - It is worth investigating heterotypic cell-cell interactions by mimicking their in vivo environment. In the present study, the mechanism of functional enhancement was investigated in a hepatocyte-fibroblast coculture with respect to the contributions of soluble factors. The enhanced hepatic functions through heterotypic interactions are effective by increasing fibroblast proliferation separately cocultured in 3D silica fabrics. The important roles of active soluble factors in heterotypic cell communications were suggested by this study using 3D proliferated tissues with satisfactory physiological morphologies in silica fabrics.

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Contribution of fibroblasts cultured on 3D silica nonwoven fabrics to cocultured hepatocytes function

Abstract

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