Connecting Nanoparticles with Different Colloidal Stability by DNA for Programmed Anisotropic Self-Assembly

Li Yu, Shota Shiraishi, Guoqing Wang, Yoshitsugu Akiyama, Tohru Takarada, Mizuo Maeda

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A strategy is described to produce an anisotropic assembly of isotropic particles. To generate the anisotropy, local-structure-sensitive colloidal stability of double-stranded DNA-modified gold nanoparticles was exploited; namely, fully matched (F) particles are spontaneously aggregated at high ionic strength, whereas terminal-mismatched (M) particles continue to stably disperse. Linear trimers prepared by aligning both the F and M particles on a DNA template in a strictly defined order undergo highly directed assembly, as revealed by electron microscopy. Importantly, the identity of the central particle controls the structural anisotropy. The trimers containing the M or F particle at the center selectively assemble in an end-to-end or side-by-side manner, respectively. Further, similar trimers having a central M larger than the peripheral F form assemblies that have small particles between the large particles. By contrast, the trimers with a central F larger than the peripheral M form an assembled structure in which the large particles are surrounded by the small particles. The anisotropy is programmable by the rule that an interparticle attractive force emerges between the F particles, probably due to blunt-end stacking of the surface-grafted DNA. This methodology could be useful to fabricate nanodevices.

Original languageEnglish
Pages (from-to)15293-15300
Number of pages8
JournalJournal of Physical Chemistry C
Issue number24
Publication statusPublished - 20 Jun 2019


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