Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(ii) in vascular endothelial cells

Takato Hara, Sayaka Sakamaki, Atsuya Ikeda, Takehiro Nakamura, Chika Yamamoto, Toshiyuki Kaji

Research output: Contribution to journalLetter

Abstract

Proteoglycans that are synthesized by vascular endothelial cells contribute to the proliferation, migration, and blood coagulation-fibrinolytic system in vascular endothelial cells. Clarification of the molecular mechanisms for proteoglycan synthesis allows understanding of the regulation of endothelial functions. The research strategy of bioorganometallics analyzes biological systems using organic-inorganic hybrid molecules as tools. The present study found dichloro(2,9-dimethyl-1,10-phenanthroline) zinc(II) and its ligand-modulated perlecan expression in vascular endothelial cells, which depends on the cell density.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalJournal of Toxicological Sciences
Volume45
Issue number2
DOIs
Publication statusPublished - 1 Jan 2020

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Keywords

  • 10-phenathroline
  • 2,9-Dimethyl-1
  • Bioorganometallics
  • Perlecan
  • Proteoglycan
  • Vascular endothelial cell
  • Zinc complex

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