Catalytic asymmetric aldol-type reaction using a chiral tin(II) Lewis acid

Shu Kobayashi, Hiromi Uchiro, Isamu Shiina, Teruaki Mukaiyama

Research output: Contribution to journalArticle

99 Citations (Scopus)


Highly diastereo- and enantioselective aldol-type reactions of a silyl enol ether with aldehydes including aromatic, aliphatic, and α,β-unsaturated ones are performed in propionitrile (solvent) by the use of a catalytic amount of chiral tin(II) Lewis acid consisting of tin(II) triflate and a chiral diamine. The asymmetric environments created by the chiral catalysts in the enantioselective aldol reaction are discussed by employing five kinds of chiral diamines.

Original languageEnglish
Pages (from-to)1761-1772
Number of pages12
Issue number9
Publication statusPublished - 26 Feb 1993

Cite this