Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94

Sho Kato, Takayuki Motoyama, Yushi Futamura, Masakazu Uramoto, Toshihiko Nogawa, Toshiaki Hayashi, Hiroshi Hirota, Akira Tanaka, Naoko Takahashi-Ando, Takashi Kamakura, Hiroyuki Osada

Research output: Contribution to journalComment/debate

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Abstract

We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97–94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.

Original languageEnglish
JournalBioscience, Biotechnology and Biochemistry
DOIs
Publication statusAccepted/In press - 1 Jan 2020

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Keywords

  • biological activity
  • biosynthesis
  • malaria
  • Natural products
  • PKS-NRPS

Cite this

Kato, S., Motoyama, T., Futamura, Y., Uramoto, M., Nogawa, T., Hayashi, T., Hirota, H., Tanaka, A., Takahashi-Ando, N., Kamakura, T., & Osada, H. (Accepted/In press). Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94. Bioscience, Biotechnology and Biochemistry. https://doi.org/10.1080/09168451.2020.1725419