TY - JOUR
T1 - Beyond the Frozen Accident
T2 - Glycine Assignment in the Genetic Code
AU - Tamura, Koji
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - tRNA with a terminal UCCA-3′ forms a structure in which the 3′-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3′ region, which places the glycine residue in close proximity to the 3′-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3′-containing tRNA (as seen in eubacterial tRNAGlys) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the “frozen accident” hypothesis.
AB - tRNA with a terminal UCCA-3′ forms a structure in which the 3′-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3′ region, which places the glycine residue in close proximity to the 3′-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3′-containing tRNA (as seen in eubacterial tRNAGlys) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the “frozen accident” hypothesis.
KW - CCA
KW - Genetic code
KW - Glycine
KW - Origin
KW - tRNA
UR - http://www.scopus.com/inward/record.url?scp=84944511722&partnerID=8YFLogxK
U2 - 10.1007/s00239-015-9694-8
DO - 10.1007/s00239-015-9694-8
M3 - Letter
C2 - 26289730
AN - SCOPUS:84944511722
SN - 0022-2844
VL - 81
SP - 69
EP - 71
JO - Journal of molecular evolution
JF - Journal of molecular evolution
IS - 3-4
ER -