Beyond the Frozen Accident: Glycine Assignment in the Genetic Code

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11 Citations (Scopus)

Abstract

tRNA with a terminal UCCA-3′ forms a structure in which the 3′-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3′ region, which places the glycine residue in close proximity to the 3′-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3′-containing tRNA (as seen in eubacterial tRNAGlys) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the “frozen accident” hypothesis.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalJournal of molecular evolution
Volume81
Issue number3-4
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • CCA
  • Genetic code
  • Glycine
  • Origin
  • tRNA

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