Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome

Takayuki Sumida; Hiroto Tsuboi; Mana Iizuka; Hiromitsu Asashima; Isao Matsumoto

doi:10.1016/B978-0-444-56378-1.00080-0

Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome

Takayuki Sumida, Hiroto Tsuboi, Mana Iizuka, Hiromitsu Asashima, Isao Matsumoto

Research Institute for Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Sjögren syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in the serum from 9–100% of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations propose the possibility that anti-M3R antibodies can serve as a new diagnostic test in patients with SS. Some of anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, the strategies designed to eliminate such pathogenic antibodies could help provide a cure to people with SS. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B-cell epitopes and the function of anti-M3R antibodies.

Original language	English
Title of host publication	Autoantibodies, Third Edition
Publisher	Elsevier
Pages	681-687
Number of pages	7
ISBN (Electronic)	9780444563781
ISBN (Print)	9780444593771
DOIs	https://doi.org/10.1016/B978-0-444-56378-1.00080-0
Publication status	Published - 1 Jan 2014

Keywords

Anti-M3R antibody
autoantibody
autoantigen
M3R
Sjögren syndrome

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10.1016/B978-0-444-56378-1.00080-0

Cite this

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title = "Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sj{\"o}gren Syndrome",

abstract = "Sj{\"o}gren syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in the serum from 9–100\% of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations propose the possibility that anti-M3R antibodies can serve as a new diagnostic test in patients with SS. Some of anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, the strategies designed to eliminate such pathogenic antibodies could help provide a cure to people with SS. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B-cell epitopes and the function of anti-M3R antibodies.",

keywords = "Anti-M3R antibody, autoantibody, autoantigen, M3R, Sj{\"o}gren syndrome",

author = "Takayuki Sumida and Hiroto Tsuboi and Mana Iizuka and Hiromitsu Asashima and Isao Matsumoto",

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T1 - Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome

AU - Sumida, Takayuki

AU - Tsuboi, Hiroto

AU - Iizuka, Mana

AU - Asashima, Hiromitsu

AU - Matsumoto, Isao

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Sjögren syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in the serum from 9–100% of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations propose the possibility that anti-M3R antibodies can serve as a new diagnostic test in patients with SS. Some of anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, the strategies designed to eliminate such pathogenic antibodies could help provide a cure to people with SS. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B-cell epitopes and the function of anti-M3R antibodies.

AB - Sjögren syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in the serum from 9–100% of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations propose the possibility that anti-M3R antibodies can serve as a new diagnostic test in patients with SS. Some of anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, the strategies designed to eliminate such pathogenic antibodies could help provide a cure to people with SS. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B-cell epitopes and the function of anti-M3R antibodies.

KW - Anti-M3R antibody

KW - autoantibody

KW - autoantigen

KW - M3R

KW - Sjögren syndrome

UR - https://www.scopus.com/pages/publications/84902071025

U2 - 10.1016/B978-0-444-56378-1.00080-0

DO - 10.1016/B978-0-444-56378-1.00080-0

M3 - Chapter

AN - SCOPUS:84902071025

SN - 9780444593771

SP - 681

EP - 687

BT - Autoantibodies, Third Edition

PB - Elsevier

ER -

Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome

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Keywords

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