Chiral crystallization of achiral compounds is attracting much attention, especially in areas of chirality research such as chiral separation and generation. Spontaneous chiral crystallization generates chirality and is a possible origin of homochirality. Although various organic and inorganic achiral compounds form chiral crystals, there are few examples of the use of this chirality for the control of enantioselective reactions of organic compounds. In this chapter, we describe how asymmetric autocatalysis can successfully utilize crystal chirality of achiral organic compounds to afford highly enantioenriched products with the absolute structure corresponding to the chirality of the crystals used.
|Title of host publication||Advances in Asymmetric Autocatalysis and Related Topics|
|Number of pages||19|
|Publication status||Published - 23 May 2017|
- Amplification of ee
- Asymmetric autocatalysis
- Chiral crystal