Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

Takayuki Sumida; Hiroto Tsuboi; Mana Iizuka; Hiromitsu Asashima; Isao Matsumoto

doi:10.1007/s10165-012-0788-5

Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

Takayuki Sumida, Hiroto Tsuboi, Mana Iizuka, Hiromitsu Asashima, Isao Matsumoto

Research Institute for Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations suggest the possibility that anti-M3R antibodies could serve as a new diagnostic test in patients with SS. Some anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, strategies designed to eliminate such pathogenic antibodies could help cure SS sufferers. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies.

Original language	English
Pages (from-to)	841-845
Number of pages	5
Journal	Modern Rheumatology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/s10165-012-0788-5
Publication status	Published - Sept 2013

Keywords

Autoantibodies
Epitopes
Function
M3 muscarinic acetylcholine receptor
Sjögren's syndrome

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10.1007/s10165-012-0788-5

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title = "Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sj{\"o}gren's syndrome",

abstract = "Sj{\"o}gren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 \% of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations suggest the possibility that anti-M3R antibodies could serve as a new diagnostic test in patients with SS. Some anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, strategies designed to eliminate such pathogenic antibodies could help cure SS sufferers. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies.",

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T1 - Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

AU - Sumida, Takayuki

AU - Tsuboi, Hiroto

AU - Iizuka, Mana

AU - Asashima, Hiromitsu

AU - Matsumoto, Isao

PY - 2013/9

Y1 - 2013/9

N2 - Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations suggest the possibility that anti-M3R antibodies could serve as a new diagnostic test in patients with SS. Some anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, strategies designed to eliminate such pathogenic antibodies could help cure SS sufferers. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies.

AB - Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies. These observations suggest the possibility that anti-M3R antibodies could serve as a new diagnostic test in patients with SS. Some anti-M3R antibodies are directly responsible for salivary underproduction in patients with SS. Thus, strategies designed to eliminate such pathogenic antibodies could help cure SS sufferers. In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies.

KW - Autoantibodies

KW - Epitopes

KW - Function

KW - M3 muscarinic acetylcholine receptor

KW - Sjögren's syndrome

UR - https://www.scopus.com/pages/publications/84885185085

U2 - 10.1007/s10165-012-0788-5

DO - 10.1007/s10165-012-0788-5

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JO - Modern Rheumatology

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Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

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Keywords

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