The EF-ring of ciguatoxin 3C, a marine toxin from the dinoflagellate Gambierdiscus toxicus, was stereoselectively synthesized by iterative use of a cyclic ether formation process based on chirality-transferring Ireland-Claisen rearrangement and ring-closing olefin metathesis.
- Fused cyclic ethers
- Ireland-Claisen rearrangement
- Natural product synthesis
- Ring closing olefin metathesis
- Stereoselective synthesis