Ag I ion mediated formation of a C-A mispair by DNA polymerases

Tatsuya Funai, Yuki Miyazaki, Megumi Aotani, Eriko Yamaguchi, Osamu Nakagawa, Shun Ichi Wada, Hidetaka Torigoe, Akira Ono, Hidehito Urata

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53 Citations (Scopus)


Silver turns up the A-C: In the presence of Ag I ions, a DNA polymerase incorporated deoxyadenosine (from dATP) at the site opposite cytosine in the template strand to afford the full-length product (see scheme), meaning that DNA polymerases prefer a C-Ag I-A base pair to the more thermodynamically stable C-Ag I-C base pair.

Original languageEnglish
Pages (from-to)6464-6466
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number26
Publication statusPublished - 25 Jun 2012



  • DNA polymerases
  • DNA recognition
  • metal ion-mediated base pairs
  • primer extension
  • silver ions

Cite this

Funai, T., Miyazaki, Y., Aotani, M., Yamaguchi, E., Nakagawa, O., Wada, S. I., Torigoe, H., Ono, A., & Urata, H. (2012). Ag I ion mediated formation of a C-A mispair by DNA polymerases. Angewandte Chemie - International Edition, 51(26), 6464-6466.