Academic detailing from the viewpoint of chemical structural formulas

Research output: Contribution to journalReview article

Abstract

In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.

Original languageEnglish
Pages (from-to)1101-1105
Number of pages5
JournalYakugaku Zasshi
Volume139
Issue number8
DOIs
Publication statusPublished - 1 Jan 2019

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Pharmaceutical Preparations
Pharmacology
Drug Compounding
Enzymes
Feces
Urine
Databases
Hormones
Breast Neoplasms
Kidney
Liver
Therapeutics

Keywords

  • Chemical structure
  • Physical characteristics
  • Structure activity correlation
  • ―academic detailing

Cite this

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abstract = "In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.",
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Academic detailing from the viewpoint of chemical structural formulas. / Wada, Takeshi.

In: Yakugaku Zasshi, Vol. 139, No. 8, 01.01.2019, p. 1101-1105.

Research output: Contribution to journalReview article

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