Abstract
In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.
| Original language | English |
|---|---|
| Pages (from-to) | 1101-1105 |
| Number of pages | 5 |
| Journal | Yakugaku Zasshi |
| Volume | 139 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Keywords
- Chemical structure
- Physical characteristics
- Structure activity correlation
- ―academic detailing
Cite this
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Academic detailing from the viewpoint of chemical structural formulas. / Wada, Takeshi.
In: Yakugaku Zasshi, Vol. 139, No. 8, 01.01.2019, p. 1101-1105.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Academic detailing from the viewpoint of chemical structural formulas
AU - Wada, Takeshi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.
AB - In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.
KW - Chemical structure
KW - Physical characteristics
KW - Structure activity correlation
KW - ―academic detailing
UR - http://www.scopus.com/inward/record.url?scp=85070537868&partnerID=8YFLogxK
U2 - 10.1248/yakushi.19-00003-6
DO - 10.1248/yakushi.19-00003-6
M3 - Review article
C2 - 31366846
AN - SCOPUS:85070537868
VL - 139
SP - 1101
EP - 1105
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 8
ER -