A rat model of oral mucositis induced by cancer chemotherapy for quantitative experiments

Issei Takeuchi, Riko Kawamata, Kimiko Makino

Research output: Contribution to journalArticle

Abstract

Background/Aim: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement. Materials and Methods: A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. The doses of 5-FU and acetic acid were examined, and a treatment experiment using Kenalog® was performed. Results: The optimal dose of the 5-FU solution and the optimal concentration of the acetic acid aqueous solution were 40 mg/kg and 25%, respectively. Treatment with Kenalog® confirmed that this model mimics immunocompromised oral mucositis. Conclusion: Compared with a mouse model, oral mucositis can be easily observed in this model and provides a large amount of oral mucosal tissue.

Original languageEnglish
Pages (from-to)2701-2706
Number of pages6
JournalAnticancer research
Volume40
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • Chemotherapy
  • Immunosuppression
  • Oral mucositis
  • Rat model

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