TY - JOUR
T1 - A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model
AU - Kemmochi, Akira
AU - Tamura, Takafumi
AU - Shimizu, Yoshio
AU - Owada, Yohei
AU - Ozawa, Yusuke
AU - Hisakura, Katsuji
AU - Oda, Tatsuya
AU - Kawano, Yayoi
AU - Hanawa, Takehisa
AU - Ohkohchi, Nobuhiro
N1 - Funding Information:
This study was supported by the Ministry of Education, Culture, Sports, Science, and Technology of Japan (KAKENHI No. 26861059, No. 16K10489 and No. 18K08641).
Publisher Copyright:
© 2020 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery
PY - 2021/2
Y1 - 2021/2
N2 - Aim: To evaluate the efficacy of a novel hydrogel sheet in preventing postoperative pancreatic fistula (POPF). Background: Postoperative pancreatic fistula is a life-threatening complication. As no study has reported the use of hydrogel sheets in preventing POPF, their effectiveness for that purpose remains unclear. Methods: A novel hydrogel sheet made of polyvinyl alcohol (PVA) was prepared by the freeze-thaw method. The pancreatic ducts and surrounding pancreatic parenchyma of rats were transected to induce a pancreatic fistula. Next, the sheet was attached to the transection site. Ascitic fluid amylase and lipase concentrations were measured. Neoveil®, a nonwoven polyglycolic acid (PGA) felt, is already clinically used as an absorbable reinforcing material at pancreatic transection sites. Neoveil® was used for comparison, as was VIEWGEL®, which is marketed as a wound dressing. Results: The hydrogel sheet remained in place 48 hours postoperatively. The ascitic amylase concentrations in the control, VIEWGEL®-treated, Neoveil®-treated, and hydrogel-treated rats, respectively, were 4992.4 ± 5355.7, 1068.4 ± 269.1, 730.2 ± 425.2, and 303.1 ± 240.1 IU/L; the ascitic lipase concentrations were 2279.8 ± 3395.2, 169.5 ± 100.6, 90.4 ± 71.0, and 86.8 ± 59.8 IU/L. The ascitic amylase and lipase levels were significantly lower in the hydrogel group than in the other groups (P <.05). Conclusions: This novel hydrogel sheet effectively prevents pancreatic fistulas and has promising clinical application potential.
AB - Aim: To evaluate the efficacy of a novel hydrogel sheet in preventing postoperative pancreatic fistula (POPF). Background: Postoperative pancreatic fistula is a life-threatening complication. As no study has reported the use of hydrogel sheets in preventing POPF, their effectiveness for that purpose remains unclear. Methods: A novel hydrogel sheet made of polyvinyl alcohol (PVA) was prepared by the freeze-thaw method. The pancreatic ducts and surrounding pancreatic parenchyma of rats were transected to induce a pancreatic fistula. Next, the sheet was attached to the transection site. Ascitic fluid amylase and lipase concentrations were measured. Neoveil®, a nonwoven polyglycolic acid (PGA) felt, is already clinically used as an absorbable reinforcing material at pancreatic transection sites. Neoveil® was used for comparison, as was VIEWGEL®, which is marketed as a wound dressing. Results: The hydrogel sheet remained in place 48 hours postoperatively. The ascitic amylase concentrations in the control, VIEWGEL®-treated, Neoveil®-treated, and hydrogel-treated rats, respectively, were 4992.4 ± 5355.7, 1068.4 ± 269.1, 730.2 ± 425.2, and 303.1 ± 240.1 IU/L; the ascitic lipase concentrations were 2279.8 ± 3395.2, 169.5 ± 100.6, 90.4 ± 71.0, and 86.8 ± 59.8 IU/L. The ascitic amylase and lipase levels were significantly lower in the hydrogel group than in the other groups (P <.05). Conclusions: This novel hydrogel sheet effectively prevents pancreatic fistulas and has promising clinical application potential.
KW - hydrogel
KW - pancreatic fistula
KW - polyvinyl alcohol
KW - postoperative pancreatic fistula
UR - http://www.scopus.com/inward/record.url?scp=85096957854&partnerID=8YFLogxK
U2 - 10.1002/jhbp.867
DO - 10.1002/jhbp.867
M3 - Article
C2 - 33179402
AN - SCOPUS:85096957854
VL - 28
SP - 192
EP - 201
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
SN - 1868-6974
IS - 2
ER -