13-Deoxo-13-iminodutomycin, a new neuroprotective compound from Streptomyces sp. RAP78

Yuta Ibusuki; Shoko Kimata; Yoichi Hayakawa

doi:10.1038/s41429-021-00488-1

13-Deoxo-13-iminodutomycin, a new neuroprotective compound from Streptomyces sp. RAP78

Yuta Ibusuki, Shoko Kimata, Yoichi Hayakawa

Department of Medicinal and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A neuroprotective compound (2) was isolated from the culture broth of the dutomycin (1) producer Streptomyces sp. RAP78. The molecular formula of 2 was established as C₄₄H₅₅NO₁₆ by high-resolution FAB-MS. The structure was determined to be a new dutomycin derivative possessing an acetimidoyl group in place of an acetyl group by NMR spectroscopic analysis. 13-Deoxo-13-iminodutomycin (2) but not dutomycin (1) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybrid cells from glutamate-induced toxicity with EC₅₀s of 0.12 µM and 0.72 µM, respectively.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	Journal of Antibiotics
Volume	75
Issue number	1
DOIs	https://doi.org/10.1038/s41429-021-00488-1
Publication status	Published - Jan 2022

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abstract = "A neuroprotective compound (2) was isolated from the culture broth of the dutomycin (1) producer Streptomyces sp. RAP78. The molecular formula of 2 was established as C44H55NO16 by high-resolution FAB-MS. The structure was determined to be a new dutomycin derivative possessing an acetimidoyl group in place of an acetyl group by NMR spectroscopic analysis. 13-Deoxo-13-iminodutomycin (2) but not dutomycin (1) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybrid cells from glutamate-induced toxicity with EC50s of 0.12 µM and 0.72 µM, respectively.",

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13-Deoxo-13-iminodutomycin, a new neuroprotective compound from Streptomyces sp. RAP78

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