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Research Output

2020

Hedgehog signaling for urogenital organogenesis and prostate cancer: An implication for the epithelial–mesenchyme interaction (EMI)

Hyuga, T., Alcantara, M., Kajioka, D., Haraguchi, R., Suzuki, K., Miyagawa, S., Kojima, Y., Hayashi, Y. & Yamada, G., 1 Jan 2020, In : International journal of molecular sciences. 21, 1, 58.

Research output: Contribution to journalReview article

Open Access
2019

Diethylstilbestrol alters the expression of activins in the neonatal mouse ovary in vitro

Oikawa, S., Kobayashi, S., Miyagawa, S., Iguchi, T. & Sato, T., 1 Jan 2019, In : In Vivo. 33, 4, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

Open Access

Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice

Acebedo, A. R., Suzuki, K., Hino, S., Alcantara, M. C., Sato, Y., Haga, H., Matsumoto, K. I., Nakao, M., Shimamura, K., Takeo, T., Nakagata, N., Miyagawa, S., Nishinakamura, R., Adelstein, R. S. & Yamada, G., 1 Dec 2019, In : Communications Biology. 2, 1, 95.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio)

Parsons, A., Lange, A., Hutchinson, T. H., Miyagawa, S., Iguchi, T., Kudoh, T. & Tyler, C. R., Apr 2019, In : Aquatic Toxicology. 209, p. 99-112 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Regulatory roles of epithelial-mesenchymal interaction (EMI) during early and androgen dependent external genitalia development

Hyuga, T., Suzuki, K., Acebedo, A. R., Hashimoto, D., Kajimoto, M., Miyagawa, S., Enmi, J. I., Yoshioka, Y. & Yamada, G., 1 Nov 2019, In : Differentiation. 110, p. 29-35 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk Factors for Hypospadias

Kojima, Y., Koguchi, T., Mizuno, K., Sato, Y., Hoshi, S., Hata, J., Nishio, H., Hashimoto, D., Matsushita, S., Suzuki, K., Miyagawa, S., Hui, C. C., Tanikawa, C., Murakami, Y., Yamada, G., Hayashi, Y. & Matsuda, K., 1 Feb 2019, In : Journal of Urology. 201, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The role of Fgf signaling on epithelial cell differentiation in mouse vagina

Hirano, Y., Suzuki, K., Iguchi, T., Yamada, G. & Miyagawa, S., 1 Jan 2019, In : In Vivo. 33, 5, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

Open Access
2018

Divergent responsiveness of two isoforms of the estrogen receptor to mixtures of contaminants of emerging concern in four vertebrates

Kohno, S., Katsu, Y., Cipoletti, N., Wang, L. C., Jorgenson, Z. G., Miyagawa, S. & Schoenfuss, H. L., May 2018, In : Journal of Applied Toxicology. 38, 5, p. 705-713 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR

Ogino, Y., Tohyama, S., Kohno, S., Toyota, K., Yamada, G., Yatsu, R., Kobayashi, T., Tatarazako, N., Sato, T., Matsubara, H., Lange, A., Tyler, C. R., Katsu, Y., Iguchi, T. & Miyagawa, S., Nov 2018, In : Journal of Steroid Biochemistry and Molecular Biology. 184, p. 38-46 9 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Identification of hepatic thyroid hormone-responsive genes in neonatal rats: Potential targets for thyroid hormone-disrupting chemicals

Fujimoto, N., Kitamura, S., Uramaru, N., Miyagawa, S. & Iguchi, T., Apr 2018, In : Toxicology Letters. 286, p. 48-53 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Juvenile hormone-independent function of Krüppel homolog 1 in early development of water flea Daphnia pulex

Miyakawa, H., Watanabe, M., Araki, M., Ogino, Y., Miyagawa, S. & Iguchi, T., Feb 2018, In : Insect Biochemistry and Molecular Biology. 93, p. 12-18 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Regulation of masculinization: Androgen signalling for external genitalia development

Matsushita, S., Suzuki, K., Murashima, A., Kajioka, D., Acebedo, A. R., Miyagawa, S., Haraguchi, R., Ogino, Y. & Yamada, G., 1 Jun 2018, In : Nature Reviews Urology. 15, 6, p. 358-368 11 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2017

Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption

Matsubara, K., Nakamura, N., Sanoh, S., Ohta, S., Kitamura, S., Uramaru, N., Miyagawa, S., Iguchi, T. & Fujimoto, N., Sep 2017, In : Journal of Applied Toxicology. 37, 9, p. 1030-1035 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals

Lange, A., Corcoran, J., Miyagawa, S., Iguchi, T., Winter, M. J. & Tyler, C. R., 1 Jun 2017, In : Toxicology in Vitro. 41, p. 114-122 9 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Establishment of estrogen receptor 1 (ESR1)-knockout medaka: ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes

Tohyama, S., Ogino, Y., Lange, A., Myosho, T., Kobayashi, T., Hirano, Y., Yamada, G., Sato, T., Tatarazako, N., Tyler, C. R., Iguchi, T. & Miyagawa, S., Aug 2017, In : Development Growth and Differentiation. 59, 6, p. 552-561 10 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2016

Characterization of evolutionary trend in squamate estrogen receptor sensitivity

Yatsu, R., Katsu, Y., Kohno, S., Mizutani, T., Ogino, Y., Ohta, Y., Myburgh, J., van Wyk, J. H., Guillette, L. J., Miyagawa, S. & Iguchi, T., 1 Nov 2016, In : General and Comparative Endocrinology. 238, p. 88-95 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Comparative developmental staging of female and male water fleas daphnia pulex and daphnia magna during embryogenesis

Toyota, K., Hiruta, C., Ogino, Y., Miyagawa, S., Okamura, T., Onishi, Y., Tatarazako, N. & Iguchi, T., 1 Feb 2016, In : Zoological Science. 33, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances

Tohyama, S., Miyagawa, S., Lange, A., Ogino, Y., Mizutani, T., Ihara, M., Tanaka, H., Tatarazako, N., Kobayashi, T., Tyler, C. R. & Iguchi, T., 1 Apr 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 158, p. 189-197 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Metabolomics reveals an involvement of pantothenate for male production responding to the short-day stimulus in the water flea, Daphnia pulex

Toyota, K., Gavin, A., Miyagawa, S., Viant, M. R. & Iguchi, T., 26 Apr 2016, In : Scientific reports. 6, 25125.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Neofunctionalization of androgen receptor by Gain-of-Function mutations in teleost fish lineage

Ogino, Y., Kuraku, S., Ishibashi, H., Miyakawa, H., Sumiya, E., Miyagawa, S., Matsubara, H., Yamada, G., Baker, M. E. & Iguchi, T., 1 Jan 2016, In : Molecular Biology and Evolution. 33, 1, p. 228-244 17 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Neverland regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea Daphnia magna, and may thus act as a target for chemical disruption of molting

Sumiya, E., Ogino, Y., Toyota, K., Miyakawa, H., Miyagawa, S. & Iguchi, T., 1 Nov 2016, In : Journal of Applied Toxicology. 36, 11, p. 1476-1485 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature-dependent sex determination and differentiation

Yatsu, R., Miyagawa, S., Kohno, S., Parrott, B. B., Yamaguchi, K., Ogino, Y., Miyakawa, H., Lowers, R. H., Shigenobu, S., Guillette, L. J. & Iguchi, T., 25 Jan 2016, In : BMC Genomics. 17, 1, 77.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)
2015

Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins

Miyagawa, S., Lange, A., Tohyama, S., Ogino, Y., Mizutani, T., Kobayashi, T., Tatarazako, N., Tyler, C. R. & Iguchi, T., 1 Mar 2015, In : Journal of Applied Toxicology. 35, 3, p. 302-309 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Differential ligand selectivity of androgen receptors α and β from Murray-Darling rainbowfish (Melanotaenia fluviatilis)

Bain, P. A., Ogino, Y., Miyagawa, S., Iguchi, T. & Kumar, A., 1 Feb 2015, In : General and Comparative Endocrinology. 212, p. 84-91 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Diofenolan induces male offspring production through binding to the juvenile hormone receptor in Daphnia magna

Abe, R., Toyota, K., Miyakawa, H., Watanabe, H., Oka, T., Miyagawa, S., Nishide, H., Uchiyama, I., Tollefsen, K. E., Iguchi, T. & Tatarazako, N., 1 Feb 2015, In : Aquatic Toxicology. 159, p. 44-51 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach

Lange, A., Sebire, M., Rostkowski, P., Mizutani, T., Miyagawa, S., Iguchi, T., Hill, E. M. & Tyler, C. R., 1 Nov 2015, In : Aquatic Toxicology. 168, p. 48-59 12 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
Open Access
13 Citations (Scopus)

Evaluation of estrogenic activity of wastewater: Comparison among in vitro ERα reporter gene assay, in vivo vitellogenin induction, and chemical analysis

Ihara, M., Kitamura, T., Kumar, V., Park, C. B., Ihara, M. O., Lee, S. J., Yamashita, N., Miyagawa, S., Iguchi, T., Okamoto, S., Suzuki, Y. & Tanaka, H., 19 May 2015, In : Environmental Science and Technology. 49, 10, p. 6319-6326 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Identification and characterization of the androgen receptor from the American Alligator, Alligator mississippiensis

Miyagawa, S., Yatsu, R., Kohno, S., Doheny, B. M., Ogino, Y., Ishibashi, H., Katsu, Y., Ohta, Y., Guillette, L. J. & Iguchi, T., 1 Aug 2015, In : Endocrinology. 156, 8, p. 2795-2806 12 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Methyl farnesoate synthesis is necessary for the environmental sex determination in the water flea Daphnia pulex

Toyota, K., Miyakawa, H., Hiruta, C., Furuta, K., Ogino, Y., Shinoda, T., Tatarazako, N., Miyagawa, S., Shaw, J. R. & Iguchi, T., 11 Aug 2015, In : Journal of Insect Physiology. 80, p. 22-30 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

NMDA receptor activation upstream of methyl farnesoate signaling for short day-induced male offspring production in the water flea, Daphnia pulex

Toyota, K., Miyakawa, H., Yamaguchi, K., Shigenobu, S., Ogino, Y., Tatarazako, N., Miyagawa, S. & Iguchi, T., 14 Mar 2015, In : BMC Genomics. 16, 1, 186.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Pten in mouse vagina

Miyagawa, S. & Iguchi, T., 1 Jan 2015, In : Oncoscience. 2, 9, p. 749-750 2 p.

Research output: Contribution to journalEditorial

Open Access

Steroid responsive regulation of IFNγ2 alternative splicing and its possible role in germ cell proliferation in medaka

Mohapatra, S., Chakraborty, T., Miyagawa, S., Zhou, L., Ohta, K., Iguchi, T. & Nagahama, Y., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 400, p. 61-70 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

TRPV4 associates environmental temperature and sex determination in the American alligator

Yatsu, R., Miyagawa, S., Kohno, S., Saito, S., Lowers, R. H., Ogino, Y., Fukuta, N., Katsu, Y., Ohta, Y., Tominaga, M., Guillette, L. J. & Iguchi, T., 18 Dec 2015, In : Scientific reports. 5, 18581.

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)

Understanding the Molecular Basis for Differences in Responses of Fish Estrogen Receptor Subtypes to Environmental Estrogens

Tohyama, S., Miyagawa, S., Lange, A., Ogino, Y., Mizutani, T., Tatarazako, N., Katsu, Y., Ihara, M., Tanaka, H., Ishibashi, H., Kobayashi, T., Tyler, C. R. & Iguchi, T., 16 Jun 2015, In : Environmental Science and Technology. 49, 12, p. 7439-7447 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina

Miyagawa, S., Sato, M., Sudo, T., Yamada, G. & Iguchi, T., 19 Feb 2015, In : Oncogene. 34, 8, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Bmp7 and lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in Medaka

Ogino, Y., Hirakawa, I., Inohaya, K., Sumiya, E., Miyagawa, S., Denslow, N., Yamada, G., Tatarazako, N. & Iguchi, T., 1 Feb 2014, In : Endocrinology. 155, 2, p. 449-462 14 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Co-occurrence of estrogenic and antiestrogenic activities in wastewater: Quantitative evaluation of balance by in vitro ERα reporter gene assay and chemical analysis

Ihara, M., Ihara, M. O., Kumar, V., Narumiya, M., Hanamoto, S., Nakada, N., Yamashita, N., Miyagawa, S., Iguchi, T. & Tanaka, H., 3 Jun 2014, In : Environmental Science and Technology. 48, 11, p. 6366-6373 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor

Miyagawa, S., Lange, A., Hirakawa, I., Tohyama, S., Ogino, Y., Mizutani, T., Kagami, Y., Kusano, T., Ihara, M., Tanaka, H., Tatarazako, N., Ohta, Y., Katsu, Y., Tyler, C. R. & Iguchi, T., 6 May 2014, In : Environmental Science and Technology. 48, 9, p. 5254-5263 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations

Miyagawa, S., Harada, M., Matsumaru, D., Tanaka, K., Inoue, C., Nakahara, C., Haraguchi, R., Matsushita, S., Suzuki, K., Nakagata, N., Ng, R. C. L., Akita, K., Lui, V. C. H. & Yamada, G., Jun 2014, In : Cell Death and Differentiation. 21, 6, p. 990-997 8 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Essential roles of epithelial bone morphogenetic protein signaling during prostatic development

Omori, A., Miyagawa, S., Ogino, Y., Harada, M., Ishii, K., Sugimura, Y., Ogino, H., Nakagata, N. & Yamada, G., Jul 2014, In : Endocrinology. 155, 7, p. 2534-2544 11 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Gonadal differentiation in reptiles exhibiting environmental sex determination

Kohno, S., Parrott, B. B., Yatsu, R., Miyagawa, S., Moore, B. C., Iguchi, T. & Guillette, L. J., 1 Sep 2014, In : Sexual Development. 8, 5, p. 208-226 19 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Molecular impact of juvenile hormone agonists on neonatal Daphnia magna

Toyota, K., Kato, Y., Miyakawa, H., Yatsu, R., Mizutani, T., Ogino, Y., Miyagawa, S., Watanabe, H., Nishide, H., Uchiyama, I., Tatarazako, N. & Iguchi, T., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 5, p. 537-544 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka

Sébillot, A., Damdimopoulou, P., Ogino, Y., Spirhanzlova, P., Miyagawa, S., Du Pasquier, D., Mouatassim, N., Iguchi, T., Lemkine, G. F., Demeneix, B. A. & Tindall, A. J., 16 Sep 2014, In : Environmental Science and Technology. 48, 18, p. 10919-10928 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Daphnia magna

Sumiya, E., Ogino, Y., Miyakawa, H., Hiruta, C., Toyota, K., Miyagawa, S. & Iguchi, T., 19 Aug 2014, In : Frontiers in Zoology. 11, 1, 60.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex

Hiruta, C., Ogino, Y., Sakuma, T., Toyota, K., Miyagawa, S., Yamamoto, T. & Iguchi, T., 1 Jan 2014, In : BMC Biotechnology. 14, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

The reproductive hormone cycle of adult female American alligators from a barrier island population

Hamlin, H. J., Lowers, R. H., Kohno, S., Mitsui-Watanabe, N., Amano, H., Hara, A., Ohta, Y., Miyagawa, S., Iguchi, T. & Guillette, L. J., 1 Jun 2014, In : Reproduction. 147, 6, p. 855-863 9 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2013

A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans

Miyakawa, H., Toyota, K., Hirakawa, I., Ogino, Y., Miyagawa, S., Oda, S., Tatarazako, N., Miura, T., Colbourne, J. K. & Iguchi, T., 12 Jun 2013, In : Nature communications. 4, 1856.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)

Cloning, expression and functional characterization of carp, cyprinus carpio, estrogen receptors and their differential activations by estrogens

Katsu, Y., Lange, A., Miyagawa, S., Urushitani, H., Tatarazako, N., Kawashima, Y., Tyler, C. R. & Iguchi, T., 1 Jan 2013, In : Journal of Applied Toxicology. 33, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Developmental disorders and altered gene expression in the tropical clawed frog (silurana tropicalis) exposed to 17α-ethinylestradiol

Hirakawa, I., Miyagawa, S., Mitsui, N., Miyahara, M., Onishi, Y., Kagami, Y., Kusano, T., Takeuchi, T., Ohta, Y. & Iguchi, T., 1 Sep 2013, In : Journal of Applied Toxicology. 33, 9, p. 1001-1010 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)